p53 Functional Inhibitors Behaving Like Pifithrin-β Counteract the Alzheimer Peptide Non-β-amyloid Component Effects in Human SH-SY5Y Cells

[Image: see text] Alzheimer’s disease (AD) develops from a complex setting of genetic and biochemical alterations, including an increased level of p53 in the brain. Here, the robust and specific activation of p53 by the fibrillar non-β-amyloid component (NAC) of AD was demonstrated in human neurobla...

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Detalhes bibliográficos
Main Authors: Da Pozzo, Eleonora, La Pietra, Valeria, Cosimelli, Barbara, Da Settimo, Federico, Giacomelli, Chiara, Marinelli, Luciana, Martini, Claudia, Novellino, Ettore, Taliani, Sabrina, Greco, Giovanni
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4030802/
https://ncbi.nlm.nih.gov/pubmed/24646317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn4002208
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