TSPO ligand residence time: a new parameter to predict compound neurosteroidogenic efficacy

The pharmacological activation of the cholesterol-binding Translocator Protein (TSPO) leads to an increase of endogenous steroids and neurosteroids determining benefic pleiotropic effects in several pathological conditions, including anxiety disorders. The relatively poor relationship between TSPO l...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Costa, Barbara, Da Pozzo, Eleonora, Giacomelli, Chiara, Barresi, Elisabetta, Taliani, Sabrina, Da Settimo, Federico, Martini, Claudia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4707509/
https://ncbi.nlm.nih.gov/pubmed/26750656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18164
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