TSPO ligand residence time: a new parameter to predict compound neurosteroidogenic efficacy

The pharmacological activation of the cholesterol-binding Translocator Protein (TSPO) leads to an increase of endogenous steroids and neurosteroids determining benefic pleiotropic effects in several pathological conditions, including anxiety disorders. The relatively poor relationship between TSPO l...

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Dades bibliogràfiques
Publicat a:Sci Rep
Autors principals: Costa, Barbara, Da Pozzo, Eleonora, Giacomelli, Chiara, Barresi, Elisabetta, Taliani, Sabrina, Da Settimo, Federico, Martini, Claudia
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4707509/
https://ncbi.nlm.nih.gov/pubmed/26750656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18164
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