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TSPO ligand residence time: a new parameter to predict compound neurosteroidogenic efficacy
The pharmacological activation of the cholesterol-binding Translocator Protein (TSPO) leads to an increase of endogenous steroids and neurosteroids determining benefic pleiotropic effects in several pathological conditions, including anxiety disorders. The relatively poor relationship between TSPO l...
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| Published in: | Sci Rep |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4707509/ https://ncbi.nlm.nih.gov/pubmed/26750656 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18164 |
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