TSPO ligand residence time: a new parameter to predict compound neurosteroidogenic efficacy

The pharmacological activation of the cholesterol-binding Translocator Protein (TSPO) leads to an increase of endogenous steroids and neurosteroids determining benefic pleiotropic effects in several pathological conditions, including anxiety disorders. The relatively poor relationship between TSPO l...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Costa, Barbara, Da Pozzo, Eleonora, Giacomelli, Chiara, Barresi, Elisabetta, Taliani, Sabrina, Da Settimo, Federico, Martini, Claudia
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4707509/
https://ncbi.nlm.nih.gov/pubmed/26750656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18164
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