Long-term treatment with naproxcinod significantly improves skeletal and cardiac disease phenotype in the mdx mouse model of dystrophy

In Duchenne muscular dystrophy (DMD) patients and the mouse model of DMD, mdx, dystrophin deficiency causes a decrease and mislocalization of muscle-specific neuronal nitric oxide synthase (nNOSμ), leading to functional impairments. Previous studies have shown that nitric oxide (NO) donation associa...

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Main Authors: Uaesoontrachoon, Kitipong, Quinn, James L, Tatem, Kathleen S, Van Der Meulen, Jack H, Yu, Qing, Phadke, Aditi, Miller, Brittany K, Gordish-Dressman, Heather, Ongini, Ennio, Miglietta, Daniela, Nagaraju, Kanneboyina
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4030778/
https://ncbi.nlm.nih.gov/pubmed/24463621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu033
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