Naproxcinod shows significant advantages over naproxen in the mdx model of Duchenne Muscular Dystrophy

BACKGROUND: In dystrophin-deficient muscles of Duchenne Muscular Dystrophy (DMD) patients and the mdx mouse model, nitric oxide (NO) signalling is impaired. Previous studies have shown that NO-donating drugs are beneficial in dystrophic mouse models. Recently, a long-term treatment (9 months) of mdx...

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Detalhes bibliográficos
Publicado no:Orphanet J Rare Dis
Main Authors: Miglietta, Daniela, De Palma, Clara, Sciorati, Clara, Vergani, Barbara, Pisa, Viviana, Villa, Antonello, Ongini, Ennio, Clementi, Emilio
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546261/
https://ncbi.nlm.nih.gov/pubmed/26296873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13023-015-0311-0
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