Revolving Door Action of BCRP Facilitates or Controls the Efflux of Flavone Glucuronides from UGT1A9-Overexpressing HeLa Cells

Cellular production of flavonoid glucuronides requires the action of both UDP-glucuronosyltransferases (UGT) and efflux transporters since glucuronides are too hydrophilic to diffuse across the cellular membrane. We determined the kinetics of efflux of 13 flavonoid glucuronides using the newly devel...

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Hlavní autoři: Wei, Yingjie, Wu, Baojian, Jiang, Wen, Yin, Taijun, Jia, Xiaobin, Basu, Sumit, Yang, Guangyi, Hu, Ming
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4030725/
https://ncbi.nlm.nih.gov/pubmed/23402418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp300562q
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