UDP-Glucuronosyltransferase (UGT) 1A9-Overexpressing HeLa Cells Is an Appropriate Tool to Delineate the Kinetic Interplay between Breast Cancer Resistance Protein (BRCP) and UGT and to Rapidly Identify the Glucuronide Substrates of BCRP

The interplay between phase II enzymes and efflux transporters leads to extensive metabolism and low bioavailability for flavonoids. To investigate the simplest interplay between one UDP-glucuronosyltransferase isoform and one efflux transporter in flavonoid disposition, engineered HeLa cells stably...

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Hlavní autoři: Jiang, Wen, Xu, Beibei, Wu, Baojian, Yu, Rong, Hu, Ming
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2012
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Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3263940/
https://ncbi.nlm.nih.gov/pubmed/22071170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.111.041467
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