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Rac1 Mediates Load-Driven Attenuation of mRNA Expression of Nerve Growth Factor Beta in Cartilage and Chondrocytes

OBJECTIVES: To determine effect of gentle loads applied to the knee on mRNA expression of nerve growth factor, particularly, the active beta subunit (NGFβ) in cartilage and chondrocyte. METHODS: Cyclic compressive loads in vivo and fluid flow in vitro were used to determine the mRNA levels. Alterati...

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Detalhes bibliográficos
Main Authors: Shim, Joon W., Hamamura, Kazunori, Chen, Andy, Wan, Qiaoqiao, Na, Sungsoo, Yokota, Hiroki
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4030644/
https://ncbi.nlm.nih.gov/pubmed/23989259
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