Intranasal H5N1 Vaccines, Adjuvanted with Chitosan Derivatives, Protect Ferrets against Highly Pathogenic Influenza Intranasal and Intratracheal Challenge

We investigated the protective efficacy of two intranasal chitosan (CSN and TM-CSN) adjuvanted H5N1 Influenza vaccines against highly pathogenic avian Influenza (HPAI) intratracheal and intranasal challenge in a ferret model. Six groups of 6 ferrets were intranasally vaccinated twice, 21 days apart,...

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Autori principali: Mann, Alex J., Noulin, Nicolas, Catchpole, Andrew, Stittelaar, Koert J., de Waal, Leon, Veldhuis Kroeze, Edwin J. B., Hinchcliffe, Michael, Smith, Alan, Montomoli, Emanuele, Piccirella, Simona, Osterhaus, Albert D. M. E., Knight, Alastair, Oxford, John S., Lapini, Giulia, Cox, Rebecca, Lambkin-Williams, Rob
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4029577/
https://ncbi.nlm.nih.gov/pubmed/24850536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0093761
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