Intranasal H5N1 Vaccines, Adjuvanted with Chitosan Derivatives, Protect Ferrets against Highly Pathogenic Influenza Intranasal and Intratracheal Challenge

We investigated the protective efficacy of two intranasal chitosan (CSN and TM-CSN) adjuvanted H5N1 Influenza vaccines against highly pathogenic avian Influenza (HPAI) intratracheal and intranasal challenge in a ferret model. Six groups of 6 ferrets were intranasally vaccinated twice, 21 days apart,...

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Detalhes bibliográficos
Main Authors: Mann, Alex J., Noulin, Nicolas, Catchpole, Andrew, Stittelaar, Koert J., de Waal, Leon, Veldhuis Kroeze, Edwin J. B., Hinchcliffe, Michael, Smith, Alan, Montomoli, Emanuele, Piccirella, Simona, Osterhaus, Albert D. M. E., Knight, Alastair, Oxford, John S., Lapini, Giulia, Cox, Rebecca, Lambkin-Williams, Rob
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4029577/
https://ncbi.nlm.nih.gov/pubmed/24850536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0093761
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