Intranasal H5N1 Vaccines, Adjuvanted with Chitosan Derivatives, Protect Ferrets against Highly Pathogenic Influenza Intranasal and Intratracheal Challenge

We investigated the protective efficacy of two intranasal chitosan (CSN and TM-CSN) adjuvanted H5N1 Influenza vaccines against highly pathogenic avian Influenza (HPAI) intratracheal and intranasal challenge in a ferret model. Six groups of 6 ferrets were intranasally vaccinated twice, 21 days apart,...

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Detaylı Bibliyografya
Asıl Yazarlar: Mann, Alex J., Noulin, Nicolas, Catchpole, Andrew, Stittelaar, Koert J., de Waal, Leon, Veldhuis Kroeze, Edwin J. B., Hinchcliffe, Michael, Smith, Alan, Montomoli, Emanuele, Piccirella, Simona, Osterhaus, Albert D. M. E., Knight, Alastair, Oxford, John S., Lapini, Giulia, Cox, Rebecca, Lambkin-Williams, Rob
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2014
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4029577/
https://ncbi.nlm.nih.gov/pubmed/24850536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0093761
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