Oligomer-targeting with a conformational antibody fragment promotes toxicity in Aβ-expressing flies

INTRODUCTION: The self-assembly of Aβ peptides into a range of conformationally heterogeneous amyloid states represents a fundamental event in Alzheimer’s disease. Within these structures oligomeric intermediates are considered to be particularly pathogenic. To test this hypothesis we have used a co...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Wacker, Jessica, Rönicke, Raik, Westermann, Martin, Wulff, Melanie, Reymann, Klaus G, Dobson, Christopher M, Horn, Uwe, Crowther, Damian C, Luheshi, Leila M, Fändrich, Marcus
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2014
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4029271/
https://ncbi.nlm.nih.gov/pubmed/24725347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-5960-2-43
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki