Molecular basis of β-amyloid oligomer recognition with a conformational antibody fragment

Oligomers are intermediates of the β-amyloid (Aβ) peptide fibrillogenic pathway and are putative pathogenic culprits in Alzheimer’s disease (AD). Here we report the biotechnological generation and biochemical characterization of an oligomer-specific antibody fragment, KW1. KW1 not only discriminates...

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Detalhes bibliográficos
Main Authors: Morgado, Isabel, Wieligmann, Karin, Bereza, Magdalena, Rönicke, Raik, Meinhardt, Katrin, Annamalai, Karthikeyan, Baumann, Monika, Wacker, Jessica, Hortschansky, Peter, Malešević, Miroslav, Parthier, Christoph, Mawrin, Christian, Schiene-Fischer, Cordelia, Reymann, Klaus G., Stubbs, Milton T., Balbach, Jochen, Görlach, Matthias, Horn, Uwe, Fändrich, Marcus
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412029/
https://ncbi.nlm.nih.gov/pubmed/22814377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206433109
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