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Mechanism of amyloid plaque formation suggests an intracellular basis of Aβ pathogenicity

The formation of extracellular amyloid plaques is a common patho-biochemical event underlying several debilitating human conditions, including Alzheimer’s disease (AD). Considerable evidence implies that AD damage arises primarily from small oligomeric amyloid forms of Aβ peptide, but the precise me...

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Autors principals: Friedrich, Ralf P., Tepper, Katharina, Rönicke, Raik, Soom, Malle, Westermann, Martin, Reymann, Klaus, Kaether, Christoph, Fändrich, Marcus
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836607/
https://ncbi.nlm.nih.gov/pubmed/20133839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0904532106
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