Oligomer-targeting with a conformational antibody fragment promotes toxicity in Aβ-expressing flies

INTRODUCTION: The self-assembly of Aβ peptides into a range of conformationally heterogeneous amyloid states represents a fundamental event in Alzheimer’s disease. Within these structures oligomeric intermediates are considered to be particularly pathogenic. To test this hypothesis we have used a co...

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Autori principali: Wacker, Jessica, Rönicke, Raik, Westermann, Martin, Wulff, Melanie, Reymann, Klaus G, Dobson, Christopher M, Horn, Uwe, Crowther, Damian C, Luheshi, Leila M, Fändrich, Marcus
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
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Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4029271/
https://ncbi.nlm.nih.gov/pubmed/24725347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-5960-2-43
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