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Comparing DNA integration site clusters with scan statistics

Motivation: Gene therapy with retroviral vectors can induce adverse effects when those vectors integrate in sensitive genomic regions. Retroviral vectors are preferred that target sensitive regions less frequently, motivating the search for localized clusters of integration sites and comparison of t...

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Hlavní autoři: Berry, Charles C., Ocwieja, Karen E., Malani, Nirav, Bushman, Frederic D.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4029028/
https://ncbi.nlm.nih.gov/pubmed/24489369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btu035
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