H-ferritin ferroxidase induces cytoprotective pathways and inhibits microvascular stasis in transgenic sickle mice

Hemolysis, oxidative stress, inflammation, vaso-occlusion, and organ infarction are hallmarks of sickle cell disease (SCD). We have previously shown that increases in heme oxygenase-1 (HO-1) activity detoxify heme and inhibit vaso-occlusion in transgenic mouse models of SCD. HO-1 releases Fe(2+) fro...

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Hlavní autoři: Vercellotti, Gregory M., Khan, Fatima B., Nguyen, Julia, Chen, Chunsheng, Bruzzone, Carol M., Bechtel, Heather, Brown, Graham, Nath, Karl A., Steer, Clifford J., Hebbel, Robert P., Belcher, John D.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2014
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4029007/
https://ncbi.nlm.nih.gov/pubmed/24860503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2014.00079
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