SPINAL NK-1 RECEPTOR EXPRESSING NEURONS MEDIATE OPIOID-INDUCED HYPERALGESIA AND ANTINOCICEPTIVE TOLERANCE VIA ACTIVATION OF DESCENDING PATHWAYS

Opioids can induce hyperalgesia in humans and in animals. Mechanisms of opiate-induced hyperalgesia and possibly of spinal antinociceptive tolerance may be linked to pronociceptive adaptations occurring at multiple levels of the nervous system including activation of descending facilitatory influenc...

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Main Authors: Vera-Portocarrero, Louis P., Zhang, En-Tan, King, Tamara, Ossipov, Michael H., Vanderah, Todd W., Lai, Josephine, Porreca, Frank
Format: Artigo
Sprog:Inglês
Udgivet: 2006
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4028682/
https://ncbi.nlm.nih.gov/pubmed/17123731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pain.2006.09.033
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