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The Role of Intracellular Linkers in Gating and Desensitization of Human Pentameric Ligand-Gated Ion Channels

It has recently been proposed that post-translational modification of not only the M3–M4 linker but also the M1–M2 linker of pentameric ligand-gated ion channels modulates function in vivo. To estimate the involvement of the M1–M2 linker in gating and desensitization, we engineered a series of mutat...

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Autori principali: Papke, David, Grosman, Claudio
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4028499/
https://ncbi.nlm.nih.gov/pubmed/24849357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5105-13.2014
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