The intracellular B30.2 domain of Butyrophilin 3A1 binds phosphoantigens to mediate activation of human Vγ9Vδ2 T cells

In humans, Vγ9Vδ2 T cells detect tumor cells and microbial infections including Mycobacterium tuberculosis through recognition of small pyrophosphate containing organic molecules known as phosphoantigens (pAgs). Key to pAg-mediated activation of Vγ9Vδ2 T cells is the butyrophilin 3A1 (BTN3A1) protei...

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Main Authors: Sandstrom, Andrew, Peigné, Cassie-Marie, Léger, Alexandra, Crooks, James E., Konczak, Fabienne, Gesnel, Marie-Claude, Breathnach, Richard, Bonneville, Marc, Scotet, Emmanuel, Adams, Erin J.
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4028361/
https://ncbi.nlm.nih.gov/pubmed/24703779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.03.003
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