RhoB mediates phosphoantigen recognition by Vγ9Vδ2 T cell receptor

Human Vγ9Vδ2 T cells respond to tumour cells by sensing elevated levels of phosphorylated intermediates of the dysregulated mevalonate pathway, which is translated into activating signals by the ubiquitously expressed butyrophilin A1 (BTN3A1) through yet unknown mechanisms. Here, we developed an unb...

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Vydáno v:Cell Rep
Hlavní autoři: Sebestyen, Zsolt, Scheper, Wouter, Vyborova, Anna, Gu, Siyi, Rychnavska, Zuzana, Schiffler, Marleen, Cleven, Astrid, Chéneau, Coraline, van Noorden, Martje, Peigné, Cassie-Marie, Olive, Daniel, Lebbink, Robert Jan, Oostvogels, Rimke, Mutis, Tuna, Schuurhuis, Gerrit-Jan, Adams, Erin J, Scotet, Emmanuel, Kuball, Jürgen
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035041/
https://ncbi.nlm.nih.gov/pubmed/27210746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.04.081
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