Nuclear localization signal deletion mutants of lamin A and progerin reveal insights into lamin A processing and emerin targeting

Lamin A is a major component of the lamina, which creates a dynamic network underneath the nuclear envelope. Mutations in the lamin A gene (LMNA) cause severe genetic disorders, one of which is Hutchinson-Gilford progeria syndrome (HGPS), a disease triggered by a dominant mutant named progerin. Unli...

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Main Authors: Wu, Di, Flannery, Andrew R, Cai, Helen, Ko, Eunae, Cao, Kan
Formato: Artigo
Idioma:Inglês
Publicado: Landes Bioscience 2014
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4028357/
https://ncbi.nlm.nih.gov/pubmed/24637396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/nucl.28068
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