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A self-reinforcing regulatory network triggered by limiting interleukin-7 activates pre-BCR signaling and differentiation
The molecular crosstalk between the interkeukin-7 receptor (IL-7R) and pre-BCR in B lymphopoiesis has been enigmatic. We demonstrate that in pre-B cells, the IL-7R, but not the pre-BCR, was coupled to the phosphatidylinositol-3-OH kinase (PI(3)K)–Akt module, signaling by which prevents Rag expressio...
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4028049/ https://ncbi.nlm.nih.gov/pubmed/22267219 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2210 |
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