Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling

The development of B cells is dependent on the sequential DNA rearrangement of immunoglobulin loci that encode subunits of the B cell receptor. The pathway navigates a crucial checkpoint that ensures expression of a signalling-competent immunoglobulin heavy chain before commitment to rearrangement a...

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Bibliographic Details
Published in:Nat Rev Immunol
Main Authors: Clark, Marcus R., Mandal, Malay, Ochiai, Kyoko, Singh, Harinder
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4276135/
https://ncbi.nlm.nih.gov/pubmed/24378843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nri3570
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