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Ras orchestrates cell cycle exit and light chain recombination during early B cell development

Signals through the pre-B cell antigen receptor (pre-BCR) and IL-7 receptor (IL-7R) coordinate pre-B cell expansion with subsequent Igκ recombination. While many downstream effectors of each receptor are known, how they integrate to mediate development has remained unclear. Herein, we report that pr...

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Detalhes bibliográficos
Main Authors: Mandal, Malay, Powers, Sarah E, Ochiai, Kyoko, Georgopoulos, Katia, Kee, Barbara, Singh, Harinder, Clark, Marcus R
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057509/
https://ncbi.nlm.nih.gov/pubmed/19734904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1785
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