Context Dependent Effects of Chimeric Peptide Morpholino Conjugates Contribute to Dystrophin Exon-skipping Efficiency

We have recently reported that cell-penetrating peptides (CPPs) and novel chimeric peptides containing CPP (referred as B peptide) and muscle-targeting peptide (referred as MSP) motifs significantly improve the systemic exon-skipping activity of morpholino phosphorodiamidate oligomers (PMOs) in dyst...

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Autores principales: Yin, HaiFang, Boisguerin, Prisca, Moulton, Hong M, Betts, Corinne, Seow, Yiqi, Boutilier, Jordan, Wang, Qingsong, Walsh, Anthony, Lebleu, Bernard, Wood, Matthew JA
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2013
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4028018/
https://ncbi.nlm.nih.gov/pubmed/24064708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2013.51
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