Hexose enhances oligonucleotide delivery and exon skipping in dystrophin-deficient mdx mice

Carbohydrate-based infusion solutions are widely used in the clinic. Here we show that co-administration of phosphorodiamidate morpholino oligomers (PMOs) with glucose enhances exon-skipping activity in Duchenne muscular dystrophy (DMD) mdx mice. We identify a glucose–fructose (GF) formulation that...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Han, Gang, Gu, Ben, Cao, Limin, Gao, Xianjun, Wang, Qingsong, Seow, Yiqi, Zhang, Ning, Wood, Matthew J. A., Yin, HaiFang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4793046/
https://ncbi.nlm.nih.gov/pubmed/26964641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10981
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