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Functional Rescue of Dystrophin-deficient mdx Mice by a Chimeric Peptide-PMO
Splice modulation using antisense oligonucleotides (AOs) has been shown to yield targeted exon exclusion to restore the open reading frame and generate truncated but partially functional dystrophin protein. This has been successfully demonstrated in dystrophin-deficient mdx mice and in Duchenne musc...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2951563/ https://ncbi.nlm.nih.gov/pubmed/20700113 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.151 |
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