Structures of Exocyclic R,R- and S,S-N(6),N(6)-(2,3-Dihydroxybutan-1,4-diyl)-2′-Deoxyadenosine Adducts Induced by 1,2,3,4-Diepoxybutane

[Image: see text] 1,3-Butadiene (BD) is an industrial and environmental chemical present in urban air and cigarette smoke, and is classified as a human carcinogen. It is oxidized by cytochrome P450 to form 1,2,3,4-diepoxybutane (DEB); DEB bis-alkylates the N(6) position of adenine in DNA. Two enanti...

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Autores principales: Kowal, Ewa A., Seneviratne, Uthpala, Wickramaratne, Susith, Doherty, Kathleen E., Cao, Xiangkun, Tretyakova, Natalia, Stone, Michael P.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2014
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027948/
https://ncbi.nlm.nih.gov/pubmed/24741991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx400472p
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