Exocyclic Deoxyadenosine Adducts of 1,2,3,4-Diepoxybutane: Synthesis, Structural Elucidation, and Mechanistic Studies

1,2,3,4-Diepoxybutane (DEB) is considered the ultimate carcinogenic metabolite of 1,3-butadiene, an important industrial chemical and environmental pollutant present in urban air. Although it preferentially modifies guanine within DNA, DEB induces a large number of A → T transversions, suggesting th...

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Detalhes bibliográficos
Main Authors: Seneviratne, Uthpala, Antsypovich, Sergey, Goggin, Melissa, Dorr, Danae Quirk, Guza, Rebecca, Moser, Adam, Thompson, Carrie, York, Darrin M., Tretyakova, Natalia
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807914/
https://ncbi.nlm.nih.gov/pubmed/19883087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx900312e
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