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3-Amido-3-aryl-piperidines: A Novel Class of Potent, Selective, and Orally Active GlyT1 Inhibitors
[Image: see text] 3-Amido-3-aryl-piperidines were discovered as a novel structural class of GlyT1 inhibitors. The structure–activity relationship, which was developed, led to the identification of highly potent compounds exhibiting excellent selectivity against the GlyT2 isoform, drug-like propertie...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , , , , , |
|---|---|
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
American Chemical
Society
2014
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| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4027785/ https://ncbi.nlm.nih.gov/pubmed/24900853 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500005m |
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