3-Amido-3-aryl-piperidines: A Novel Class of Potent, Selective, and Orally Active GlyT1 Inhibitors

[Image: see text] 3-Amido-3-aryl-piperidines were discovered as a novel structural class of GlyT1 inhibitors. The structure–activity relationship, which was developed, led to the identification of highly potent compounds exhibiting excellent selectivity against the GlyT2 isoform, drug-like propertie...

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Detalhes bibliográficos
Main Authors: Pinard, Emmanuel, Alberati, Daniela, Alvarez-Sanchez, Ruben, Brom, Virginie, Burner, Serge, Fischer, Holger, Hauser, Nicole, Kolczewski, Sabine, Lengyel, Judith, Mory, Roland, Saladin, Christian, Schulz-Gasch, Tanja, Stalder, Henri
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027785/
https://ncbi.nlm.nih.gov/pubmed/24900853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500005m
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