Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 2. Development of a [3.3.0]-based series and other piperidine bioisosteres

This letter describes the development and SAR of a novel series of GlyT1 inhibitors derived from a scaffold hopping approach, in lieu of an HTS campaign, which provided intellectual property position. Members within this new [3.3.0]-based series displayed excellent GlyT1 potency, selectivity, free f...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Sheffler, Douglas J., Nedelovych, Michael T., Williams, Richard, Turner, Stephen C., Duerk, Brittany B., Robbins, Megan R., Jadhav, Sataya B., Niswender, Colleen M., Jones, Carrie K., Conn, P. Jeffrey, Daniels, R. Nathan, Lindsley, Craig W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3951244/
https://ncbi.nlm.nih.gov/pubmed/24462664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.01.011
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados