Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 2. Development of a [3.3.0]-based series and other piperidine bioisosteres

This letter describes the development and SAR of a novel series of GlyT1 inhibitors derived from a scaffold hopping approach, in lieu of an HTS campaign, which provided intellectual property position. Members within this new [3.3.0]-based series displayed excellent GlyT1 potency, selectivity, free f...

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Bibliografiske detaljer
Main Authors: Sheffler, Douglas J., Nedelovych, Michael T., Williams, Richard, Turner, Stephen C., Duerk, Brittany B., Robbins, Megan R., Jadhav, Sataya B., Niswender, Colleen M., Jones, Carrie K., Conn, P. Jeffrey, Daniels, R. Nathan, Lindsley, Craig W.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3951244/
https://ncbi.nlm.nih.gov/pubmed/24462664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.01.011
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