Discovery of a novel, CNS penetrant M(4) PAM chemotype based on a 6-fluoro-4-(piperidin-1-yl)quinoline-3-carbonitrile core

This Letter details the discovery and subsequent optimization of a novel M(4) PAM scaffold based on an 6-fluoro-4-(piperidin-1-yl)quinoline-3-carbonitrile core, which represents a distinct departure from the classical M(4) PAM chemotypes. Optimized compounds in this series demonstrated improved M(4)...

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Publicado no:Bioorg Med Chem Lett
Main Authors: Bewley, Blake R., Spearing, Paul K., Weiner, Rebecca L., Luscombe, Vincent B., Zhan, Xiaoyan, Chang, Sichen, Cho, Hyekyung P., Rodriguez, Alice L., Niswender, Colleen M., Conn, P. Jeffrey, Bridges, Thomas M., Engers, Darren W., Lindsley, Craig W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5688877/
https://ncbi.nlm.nih.gov/pubmed/28866269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.08.043
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