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High Content Screening of Diverse Compound Libraries Identifies Potent Modulators of Tubulin Dynamics

[Image: see text] Tubulin modulating agents such as the taxanes are among the most effective antimitotic cancer drugs, although resistance and toxicity present significant problems in their clinical use. However, most tubulin modulators are derived from complex natural products, which can make modif...

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Bibliografski detalji
Glavni autori: Laraia, Luca, Stokes, Jamie, Emery, Amy, McKenzie, Grahame J., Venkitaraman, Ashok R., Spring, David R.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2014
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027768/
https://ncbi.nlm.nih.gov/pubmed/24900887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5000564
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