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High Content Screening of Diverse Compound Libraries Identifies Potent Modulators of Tubulin Dynamics

[Image: see text] Tubulin modulating agents such as the taxanes are among the most effective antimitotic cancer drugs, although resistance and toxicity present significant problems in their clinical use. However, most tubulin modulators are derived from complex natural products, which can make modif...

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Main Authors: Laraia, Luca, Stokes, Jamie, Emery, Amy, McKenzie, Grahame J., Venkitaraman, Ashok R., Spring, David R.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Chemical Society 2014
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027768/
https://ncbi.nlm.nih.gov/pubmed/24900887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5000564
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