Kinesin Spindle Protein Inhibitors with Diaryl Amine Scaffolds: Crystal Packing Analysis for Improved Aqueous Solubility

[Image: see text] Diaryl amine derivatives have been designed and synthesized as novel kinesin spindle protein (KSP) inhibitors based on planar carbazole-type KSP inhibitors with poor aqueous solubility. The new generation of inhibitors was found to show comparable inhibitory activity and high selec...

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Główni autorzy: Takeuchi, Tomoki, Oishi, Shinya, Kaneda, Masato, Ohno, Hiroaki, Nakamura, Shinya, Nakanishi, Isao, Yamane, Masayoshi, Sawada, Jun-ichi, Asai, Akira, Fujii, Nobutaka
Format: Artigo
Język:Inglês
Wydane: American Chemical Society 2014
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027754/
https://ncbi.nlm.nih.gov/pubmed/24900881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500016j
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