A microtubule polymerase cooperates with the kinesin-6 motor and a microtubule cross-linker to promote bipolar spindle assembly in the absence of kinesin-5 and kinesin-14 in fission yeast

Accurate chromosome segregation relies on the bipolar mitotic spindle. In many eukaryotes, spindle formation is driven by the plus-end–directed motor kinesin-5 that generates outward force to establish spindle bipolarity. Its inhibition leads to the emergence of monopolar spindles with mitotic arres...

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Veröffentlicht in:Mol Biol Cell
Hauptverfasser: Yukawa, Masashi, Kawakami, Tomoki, Okazaki, Masaki, Kume, Kazunori, Tang, Ngang Heok, Toda, Takashi
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5706992/
https://ncbi.nlm.nih.gov/pubmed/29021344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E17-08-0497
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