Optimizing the Physicochemical Properties of Raf/MEK Inhibitors by Nitrogen Scanning

[Image: see text] Substituting a carbon atom with a nitrogen atom (nitrogen substitution) on an aromatic ring in our leads 11a and 13g by applying nitrogen scanning afforded a set of compounds that improved not only the solubility but also the metabolic stability. The impact after nitrogen substitut...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Aoki, Toshihiro, Hyohdoh, Ikumi, Furuichi, Noriyuki, Ozawa, Sawako, Watanabe, Fumio, Matsushita, Masayuki, Sakaitani, Masahiro, Morikami, Kenji, Takanashi, Kenji, Harada, Naoki, Tomii, Yasushi, Shiraki, Koji, Furumoto, Kentaro, Tabo, Mitsuyasu, Yoshinari, Kiyoshi, Ori, Kazutomo, Aoki, Yuko, Shimma, Nobuo, Iikura, Hitoshi
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027752/
https://ncbi.nlm.nih.gov/pubmed/24900832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400379x
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados