Fluorine Scanning by Nonselective Fluorination: Enhancing Raf/MEK Inhibition while Keeping Physicochemical Properties

[Image: see text] A facile methodology effective in obtaining a set of compounds monofluorinated at various positions (fluorine scan) by chemical synthesis is reported. Direct and nonselective fluorination reactions of our lead compound 1a and key intermediate 2a worked efficiently to afford a total...

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Autors principals: Hyohdoh, Ikumi, Furuichi, Noriyuki, Aoki, Toshihiro, Itezono, Yoshiko, Shirai, Haruyoshi, Ozawa, Sawako, Watanabe, Fumio, Matsushita, Masayuki, Sakaitani, Masahiro, Ho, Pil-Su, Takanashi, Kenji, Harada, Naoki, Tomii, Yasushi, Yoshinari, Kiyoshi, Ori, Kazutomo, Tabo, Mitsuyasu, Aoki, Yuko, Shimma, Nobuo, Iikura, Hitoshi
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2013
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027529/
https://ncbi.nlm.nih.gov/pubmed/24900605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml4002419
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