Fluorine Scanning by Nonselective Fluorination: Enhancing Raf/MEK Inhibition while Keeping Physicochemical Properties

[Image: see text] A facile methodology effective in obtaining a set of compounds monofluorinated at various positions (fluorine scan) by chemical synthesis is reported. Direct and nonselective fluorination reactions of our lead compound 1a and key intermediate 2a worked efficiently to afford a total...

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主要な著者: Hyohdoh, Ikumi, Furuichi, Noriyuki, Aoki, Toshihiro, Itezono, Yoshiko, Shirai, Haruyoshi, Ozawa, Sawako, Watanabe, Fumio, Matsushita, Masayuki, Sakaitani, Masahiro, Ho, Pil-Su, Takanashi, Kenji, Harada, Naoki, Tomii, Yasushi, Yoshinari, Kiyoshi, Ori, Kazutomo, Tabo, Mitsuyasu, Aoki, Yuko, Shimma, Nobuo, Iikura, Hitoshi
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2013
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027529/
https://ncbi.nlm.nih.gov/pubmed/24900605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml4002419
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