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Phenylalanine-Based Inactivator of AKT Kinase: Design, Synthesis, and Biological Evaluation
[Image: see text] Strategies to inhibit kinases by targeting the substrate binding site offer many advantages, including naturally evolved selectivity filters, but normally suffer from poor potency. In this work we propose a strategy to design and prepare covalent substrate-competitive kinase inhibi...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4027749/ https://ncbi.nlm.nih.gov/pubmed/24900862 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500088x |
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