Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor

[Image: see text] The identification and in vitro and in vivo characterization of a potent SHI-1:2 are described. Kinetic analysis indicated that biaryl inhibitors exhibit slow binding kinetics in isolated HDAC1 and HDAC2 preparations. Delayed histone hyperacetylation and gene expression changes wer...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Methot, Joey L., Hoffman, Dawn Mampreian, Witter, David J., Stanton, Matthew G., Harrington, Paul, Hamblett, Christopher, Siliphaivanh, Phieng, Wilson, Kevin, Hubbs, Jed, Heidebrecht, Richard, Kral, Astrid M., Ozerova, Nicole, Fleming, Judith C., Wang, Hongmei, Szewczak, Alexander A., Middleton, Richard E., Hughes, Bethany, Cruz, Jonathan C., Haines, Brian B., Chenard, Melissa, Kenific, Candia M., Harsch, Andreas, Secrist, J. Paul, Miller, Thomas A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2014
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027730/
https://ncbi.nlm.nih.gov/pubmed/24900838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml4004233
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge