Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor

[Image: see text] The identification and in vitro and in vivo characterization of a potent SHI-1:2 are described. Kinetic analysis indicated that biaryl inhibitors exhibit slow binding kinetics in isolated HDAC1 and HDAC2 preparations. Delayed histone hyperacetylation and gene expression changes wer...

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Detalhes bibliográficos
Main Authors: Methot, Joey L., Hoffman, Dawn Mampreian, Witter, David J., Stanton, Matthew G., Harrington, Paul, Hamblett, Christopher, Siliphaivanh, Phieng, Wilson, Kevin, Hubbs, Jed, Heidebrecht, Richard, Kral, Astrid M., Ozerova, Nicole, Fleming, Judith C., Wang, Hongmei, Szewczak, Alexander A., Middleton, Richard E., Hughes, Bethany, Cruz, Jonathan C., Haines, Brian B., Chenard, Melissa, Kenific, Candia M., Harsch, Andreas, Secrist, J. Paul, Miller, Thomas A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027730/
https://ncbi.nlm.nih.gov/pubmed/24900838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml4004233
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