Genes Are Often Sheltered from the Global Histone Hyperacetylation Induced by HDAC Inhibitors

Histone deacetylase inhibitors (HDACi) are increasingly used as therapeutic agents, but the mechanisms by which they alter cell behaviour remain unclear. Here we use microarray expression analysis to show that only a small proportion of genes (∼9%) have altered transcript levels after treating HL60...

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Detalhes bibliográficos
Main Authors: Halsall, John, Gupta, Vibhor, O'Neill, Laura P., Turner, Bryan M., Nightingale, Karl P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3316569/
https://ncbi.nlm.nih.gov/pubmed/22479401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033453
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