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Genes Are Often Sheltered from the Global Histone Hyperacetylation Induced by HDAC Inhibitors

Histone deacetylase inhibitors (HDACi) are increasingly used as therapeutic agents, but the mechanisms by which they alter cell behaviour remain unclear. Here we use microarray expression analysis to show that only a small proportion of genes (∼9%) have altered transcript levels after treating HL60...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Halsall, John, Gupta, Vibhor, O'Neill, Laura P., Turner, Bryan M., Nightingale, Karl P.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Public Library of Science 2012
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3316569/
https://ncbi.nlm.nih.gov/pubmed/22479401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033453
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