Genes Are Often Sheltered from the Global Histone Hyperacetylation Induced by HDAC Inhibitors

Histone deacetylase inhibitors (HDACi) are increasingly used as therapeutic agents, but the mechanisms by which they alter cell behaviour remain unclear. Here we use microarray expression analysis to show that only a small proportion of genes (∼9%) have altered transcript levels after treating HL60...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Halsall, John, Gupta, Vibhor, O'Neill, Laura P., Turner, Bryan M., Nightingale, Karl P.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2012
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3316569/
https://ncbi.nlm.nih.gov/pubmed/22479401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033453
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires