The histone deacetylase inhibitor sodium valproate causes limited transcriptional change in mouse embryonic stem cells but selectively overrides Polycomb-mediated Hoxb silencing

BACKGROUND: Histone deacetylase inhibitors (HDACi) cause histone hyperacetylation and H3K4 hypermethylation in various cell types. They find clinical application as anti-epileptics and chemotherapeutic agents, but the pathways through which they operate remain unclear. Surprisingly, changes in gene...

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Main Authors: Boudadi, Elsa, Stower, Hannah, Halsall, John A, Rutledge, Charlotte E, Leeb, Martin, Wutz, Anton, O’Neill, Laura P, Nightingale, Karl P, Turner, Bryan M
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2013
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3769143/
https://ncbi.nlm.nih.gov/pubmed/23634885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8935-6-11
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