Total Synthesis of Thiaplakortone A: Derivatives as Metabolically Stable Leads for the Treatment of Malaria

[Image: see text] Thiaplakortone A (3a), an antimalarial natural product, was prepared by an operationally simple and scalable synthesis. In our efforts to deliver a lead compound with improved potency, metabolic stability, and selectivity, the synthesis was diverted to access a series of analogues....

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Autori principali: Pouwer, Rebecca H., Deydier, Sophie M., Le, Phuc Van, Schwartz, Brett D., Franken, Nicole C., Davis, Rohan A., Coster, Mark J., Charman, Susan A., Edstein, Michael D., Skinner-Adams, Tina S., Andrews, Katherine T., Jenkins, Ian D., Quinn, Ronald J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2013
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027726/
https://ncbi.nlm.nih.gov/pubmed/24900794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400447v
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