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Synthesis and Antiplasmodial Evaluation of Analogues Based on the Tricyclic Core of Thiaplakortones A–D

Six regioisomers associated with the tricyclic core of thiaplakortones A–D have been synthesized. Reaction of 1H-indole-4,7-dione and 1-tosyl-1H-indole-4,7-dione with 2-aminoethanesulfinic acid afforded a regioisomeric series, which was subsequently deprotected and oxidized to yield the tricyclic co...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mar Drugs
Prif Awduron: Schwartz, Brett D., Coster, Mark J., Skinner-Adams, Tina S., Andrews, Katherine T., White, Jonathan M., Davis, Rohan A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4584354/
https://ncbi.nlm.nih.gov/pubmed/26389920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md13095784
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