Total Synthesis of Thiaplakortone A: Derivatives as Metabolically Stable Leads for the Treatment of Malaria

[Image: see text] Thiaplakortone A (3a), an antimalarial natural product, was prepared by an operationally simple and scalable synthesis. In our efforts to deliver a lead compound with improved potency, metabolic stability, and selectivity, the synthesis was diverted to access a series of analogues....

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Pouwer, Rebecca H., Deydier, Sophie M., Le, Phuc Van, Schwartz, Brett D., Franken, Nicole C., Davis, Rohan A., Coster, Mark J., Charman, Susan A., Edstein, Michael D., Skinner-Adams, Tina S., Andrews, Katherine T., Jenkins, Ian D., Quinn, Ronald J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027726/
https://ncbi.nlm.nih.gov/pubmed/24900794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400447v
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados