Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region

[Image: see text] Herein, novel hepatitis C virus NS3/4A protease inhibitors based on a P2 pyrimidinyloxyphenylglycine in combination with various regioisomers of an aryl acyl sulfonamide functionality in P1 are presented. The P1′ 4-(trifluoromethyl)phenyl side chain was shown to be particularly ben...

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Detalhes bibliográficos
Main Authors: Lampa, Anna K., Bergman, Sara M., Gustafsson, Sofia S., Alogheli, Hiba, Åkerblom, Eva B., Lindeberg, Gunnar G., Svensson, Richard M., Artursson, Per, Danielson, U. Helena, Karlén, Anders, Sandström, Anja
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027635/
https://ncbi.nlm.nih.gov/pubmed/24900813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400217r
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