Exploration and Pharmacokinetic Profiling of Phenylalanine Based Carbamates as Novel Substance P 1–7 Analogues

[Image: see text] The bioactive metabolite of Substance P, the heptapeptide SP(1–7) (H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-OH), has been shown to attenuate signs of hyperalgesia in diabetic mice, which indicate a possible use of compounds targeting the SP(1–7) binding site as analgesics for neuropathic pain...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Fransson, Rebecca, Nordvall, Gunnar, Bylund, Johan, Carlsson-Jonsson, Anna, Kratz, Jadel M., Svensson, Richard, Artursson, Per, Hallberg, Mathias, Sandström, Anja
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4265825/
https://ncbi.nlm.nih.gov/pubmed/25516784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5002954
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